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Article

An Osteoporosis Susceptibility Allele at 11p15 Regulates SOX6 Expression by Modulating TCF4 Chromatin Binding.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2022

Zhu Dong-Li, Chen Xiao-Feng, Zhou Xiao-Rong, Hu Shou-Ye, Tuo Xiao-Mei, Hao Ruo-Han, Dong Shan-Shan, Jiang Feng, Rong Yu, Yang Tie-Lin, Yang Zhi, Guo Yan

Abstract excerpt

Osteoporosis is an age-related complex disease clinically diagnosed with bone mineral density (BMD). Although several genomewide association studies (GWASs) have discovered multiple noncoding genetic variants at 11p15 influencing osteoporosis risk, the functional mechanisms of these variants remain unknown. Through integrating bioinformatics and functional experiments, a potential functional single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35373860
DOI: 10.1002/jbmr.4554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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