Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human ALOX12, but not ALOX15, is associated with BMD in white men and women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2006

Ichikawa Shoji, Koller Daniel L, Johnson Michelle L, Lai Dongbing, Xuei Xiaoling, Edenberg Howard J, Klein Robert F, Orwoll Eric S, Hui Siu L, Foroud Tatiana M, Peacock Munro, Econs Michael J

Abstract excerpt

UNLABELLED: The Alox15 gene was recently identified as a negative regulator of peak BMD in mice. Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD. INTRODUCTION: Osteoporosis is a complex disease with both genetic and environmental risk factors. A major determinant of osteoporosis is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Arachidonate 12-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arachidonate 15-Lipoxygenase

Share to Bone Density

Share to Bone health and osteoporosis research

Share to Polymorphism, Single Nucleotide

Share to Siblings

Share to White People

Source

Identifiers

PMID: 16598376
DOI: 10.1359/jbmr.051212

Genes

ALOX12
ALOX15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human ALOX12, but not ALOX15, is associated with BMD in white men and women.PMID 16598376Read ↗

Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density.Semantic proximity Read ↗

A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women.Semantic proximity Read ↗

Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.Semantic proximity Read ↗

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.Semantic proximity Read ↗

Association studies of ALOX5 and bone mineral density in healthy adults.Semantic proximity Read ↗

Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring.Semantic proximity Read ↗

Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis.Semantic proximity Read ↗

Association of IL-15 polymorphisms with bone mineral density in postmenopausal Korean women.Semantic proximity Read ↗

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15.Semantic proximity Read ↗

Genetic determinants of bone mass.Semantic proximity Read ↗

Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.Semantic proximity Read ↗

Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.