Article
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns.
American journal of human genetics - 7 Nov 2024
Deal Milena, Kar Asha, Lee Seung Hyuk T, Alvarez Marcus, Rajkumar Sandhya, Arasu Uma Thanigai, Kaminska Dorota, Männistö Ville, Heinonen Sini, van der Kolk Birgitta W, Säiläkivi Ulla, Saarinen Tuure, Juuti Anne, Pihlajamäki Jussi, Kaikkonen Minna U, Laakso Markku, Pietiläinen Kirsi H, Pajukanta Päivi
Abstract excerpt
Mechanisms of abdominal obesity GWAS variants have remained largely unknown. To elucidate these mechanisms, we leveraged subcutaneous adipose tissue (SAT) single nucleus RNA-sequencing and genomics data. After discovering that heritability of abdominal obesity is enriched in adipocytes, we focused on a SAT unique adipocyte marker gene, the transcription factor TBX15, and its abdominal obesity-associated...
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