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Article

Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.

Cell systems - 25 Jan 2017

Calabrese Gina M, Mesner Larry D, Stains Joseph P, Tommasini Steven M, Horowitz Mark C, Rosen Clifford J, Farber Charles R

Abstract excerpt

Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. Genome-wide association studies (GWAS) for BMD have identified dozens of associations; yet, the genes responsible for most associations remain elusive. Here, we used a bone co-expression network to predict causal genes at BMD GWAS loci based on the premise that genes underlying a disease are often functionally related and...

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Source

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Identifiers

PMID: 27866947
DOI: 10.1016/j.cels.2016.10.014
PMCID: PMC5269473

Genes

MARK3
SPTBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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