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Article

Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.

Genome medicine - 7 Dec 2015

Hunt Lilian E, Noyvert Boris, Bhaw-Rosun Leena, Sesay Abdul K, Paternoster Lavinia, Nohr Ellen A, Davey Smith George, Tommerup Niels, Sørensen Thorkild I A, Elgar Greg

Abstract excerpt

BACKGROUND: Association studies have identified a number of loci that contribute to an increased body mass index (BMI), the strongest of which is in the first intron of the FTO gene on human chromosome 16q12.2. However, this region is both non-coding and under strong linkage disequilibrium, making it recalcitrant to functional interpretation. Furthermore, the FTO gene is located within a complex cis-regulatory...

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Share to Adaptor Proteins, Signal Transducing
Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

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Share to Homeodomain Proteins

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Source

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Identifiers

PMID: 26642925
DOI: 10.1186/s13073-015-0250-3
PMCID: PMC4671217

Genes

FTO
IRX5
IRX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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