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Article

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.

Blood - 19 Mar 2020

Barz Malwine J, Hof Jana, Groeneveld-Krentz Stefanie, Loh Jui Wan, Szymansky Annabell, Astrahantseff Kathy, von Stackelberg Arend, Khiabanian Hossein, Ferrando Adolfo A, Eckert Cornelia, Kirschner-Schwabe Renate

Abstract excerpt

Activating mutations in cytosolic 5'-nucleotidase II (NT5C2) are considered to drive relapse formation in acute lymphoblastic leukemia (ALL) by conferring purine analog resistance. To examine the clinical effects of NT5C2 mutations in relapsed ALL, we analyzed NT5C2 in 455 relapsed B-cell precursor ALL patients treated within the ALL-REZ BFM 2002 relapse trial using sequencing and sensitive allele-specific...

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Identifiers

PMID: 31971569
DOI: 10.1182/blood.2019002499
PMCID: PMC7218751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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