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Article

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

Nature medicine - 1 Mar 2013

Tzoneva Gannie, Perez-Garcia Arianne, Carpenter Zachary, Khiabanian Hossein, Tosello Valeria, Allegretta Maddalena, Paietta Elisabeth, Racevskis Janis, Rowe Jacob M, Tallman Martin S, Paganin Maddalena, Basso Giuseppe, Hof Jana, Kirschner-Schwabe Renate, Palomero Teresa, Rabadan Raul, Ferrando Adolfo

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult patients with ALL do not achieve a complete remission or relapse after intensified chemotherapy, making disease relapse and resistance to therapy the most substantial challenge in the treatment...

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Identifiers

PMID: 23377281
DOI: 10.1038/nm.3078
PMCID: PMC3594483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.PMID 23377281Read ↗

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