Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia.

Nature genetics - 1 Mar 2013

Meyer Julia A, Wang Jinhua, Hogan Laura E, Yang Jun J, Dandekar Smita, Patel Jay P, Tang Zuojian, Zumbo Paul, Li Sheng, Zavadil Jiri, Levine Ross L, Cardozo Timothy, Hunger Stephen P, Raetz Elizabeth A, Evans William E, Morrison Debra J, Mason Christopher E, Carroll William L

Abstract excerpt

Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report the transcriptome profiles of matched diagnosis and relapse bone marrow specimens from ten individuals with pediatric B-lymphoblastic leukemia using RNA sequencing. Transcriptome sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5'-Nucleotidase
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Protein Conformation

Share to Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 23377183
DOI: 10.1038/ng.2558
PMCID: PMC3681285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia.PMID 23377183Read ↗

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.Semantic proximity Read ↗

An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALLSemantic proximity Read ↗

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.Semantic proximity Read ↗

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.Semantic proximity Read ↗

Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.Semantic proximity Read ↗

Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Single-Cell Sequencing Reveals Extensive Genetic Diversity Underlying Pediatric ALL Treatment ComplexitySemantic proximity Read ↗

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.