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Genetics and mechanisms of NT5C2-driven chemotherapy resistance in relapsed ALL

26 Mar 2019

Abstract excerpt

Abstract Mutations in the cytosolic 5′ nucleotidase II (NT5C2) gene drive resistance to thiopurine chemotherapy in relapsed acute lymphoblastic leukemia (ALL). Mechanistically, NT5C2 mutant proteins have increased nucleotidase activity as a result of altered activating and autoregulatory switch-off mechanisms. Leukemias with NT5C2 mutations are chemoresistant to 6-mercaptopurine yet show impaired proliferation...

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PMID: 30910786
DOI: 10.1182/blood-2019-01-852392

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