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Article

FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.

Nature communications - 21 Jan 2020

Yan Tingxiang, Liang Jingjing, Gao Ju, Wang Luwen, Fujioka Hisashi, Zhu Xiaofeng, Wang Xinglong

Abstract excerpt

Alzheimer's disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and AD-related regional brain atrophy. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31964863
DOI: 10.1038/s41467-019-13962-0
PMCID: PMC6972869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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