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Article

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.

The Journal of biological chemistry - 12 Aug 2005

Matsuda Shuji, Giliberto Luca, Matsuda Yukiko, Davies Peter, McGowan Eileen, Pickford Fiona, Ghiso Jorge, Frangione Blas, D'Adamio Luciano

Abstract excerpt

Alzheimer disease (AD), the most common senile dementia, is characterized by amyloid plaques, vascular amyloid, neurofibrillary tangles, and progressive neurodegeneration. Amyloid is mainly composed by amyloid-beta (A(beta)) peptides, which are derive from processing of the beta-amyloid precursor protein (APP), better named amyloid-beta precursor protein (A(beta)PP), by secretases. The A(beta)PP intracellular...

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Source

Identifiers

PMID: 15983050
DOI: 10.1074/jbc.C500217200

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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