Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.

doi:10.3233/jad-2008-13102

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Article

Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.

Journal of Alzheimer's disease : JAD - 1 Feb 2008

Guerreiro Nelson, Staufenbiel Matthias, Gomez-Mancilla Baltazar

Abstract excerpt

Alzheimer's disease is the most prevalent form of dementia associated with aging in the human population for which there is no biomarker for accurate and effective diagnosis at its early stage or monitoring of disease progression. In this study, we used 2-D DIGE to identify Alzheimer's disease-related proteins in the brains of APP23 mice used as a model for studying cerebral amyloidosis. Protein expression...

Topics

Amyloid beta-Protein Precursor
Amyloidosis
Animals
Brain
Databases, Nucleic Acid
Electrophoresis, Gel, Two-Dimensional
Gene Expression Profiling
Mice
Mice, Transgenic
Phenotype
Plaque, Amyloid
Proteomics

Source

Open in PubMed

Identifiers

PMID: 18334753
DOI: 10.3233/jad-2008-13102

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