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The Transglutaminase-2 Interactome in the APP23 Mouse Model of Alzheimer’s Disease

24 Jan 2022

Abstract excerpt

Amyloid-beta (Aβ) deposition in the brain is closely linked with the development of Alzheimer’s disease (AD). Unfortunately, therapies specifically targeting Aβ deposition have failed to reach their primary clinical endpoints, emphasizing the need to broaden the search strategy for alternative targets/mechanisms. Transglutaminase-2 (TG2) catalyzes post-translational modifications, is present in AD lesions and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35159198
DOI: 10.3390/cells11030389

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