Alzheimer's disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment.

doi:10.1016/j.neulet.2021.136419

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Article

Alzheimer's disease susceptibility locus in CD2AP is associated with increased cerebrospinal fluid tau levels in mild cognitive impairment.

Neuroscience letters - 6 Feb 2022

Xue Yan-Yan, Chen Yi-He, Lin Rong-Rong, Huang Hui-Fen, Wu Zhi-Ying, Tao Qing-Qing

Abstract excerpt

INTRODUCTION: Rs9296559 within CD2-associated protein (CD2AP) has been identified as a susceptibility locus for Alzheimer's disease (AD). Recent studies indicated that CD2AP functioned as a regulator of endocytic trafficking to modulate the β-amyloid (Aβ) generation in neurons. Moreover, knockdown of cindr, the Drosophila ortholog of CD2AP, enhanced tau-induced neurodegeneration, implying CD2AP also participated...

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PMID: 34958910
DOI: 10.1016/j.neulet.2021.136419

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