Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of BRI2 in dementia.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Del Campo Marta, Teunissen Charlotte E

Abstract excerpt

Alzheimer's disease (AD), the most common form of dementia, shares clinical and pathological similarities with familial British and Danish dementias (FBD and FDD). Whereas the etiology of sporadic AD remains unclear, familial AD is linked to mutations in amyloid-β protein precursor (AβPP), presenilin 1 (PS1), and presenilin 2 (PS2). Similarly, FBD and FDD originate from mutations in the BRI2 gene (or ITM2b),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Brain
Share to Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Membrane Glycoproteins

Share to Models, Biological

Share to Mutation

Source

Identifiers

PMID: 24473189
DOI: 10.3233/JAD-131364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of BRI2 in dementia.PMID 24473189Read ↗

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.Semantic proximity Read ↗

BRI2 as an anti-Alzheimer gene.Semantic proximity Read ↗

BRI2 as a central protein involved in neurodegeneration.Semantic proximity Read ↗

Amyloid and intracellular accumulation of BRI2.Semantic proximity Read ↗

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.Semantic proximity Read ↗

Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.Semantic proximity Read ↗

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.Semantic proximity Read ↗

Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.Semantic proximity Read ↗

Memory Deficits Due to Familial British Dementia<i>BRI2</i>Mutation Are Caused by Loss of<i>BRI2</i>Function Rather than AmyloidosisSemantic proximity Read ↗

Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission.Semantic proximity Read ↗

BRI2 and BRI3 are functionally distinct phosphoproteins.Semantic proximity Read ↗

Sporadic and Familial Cerebral Amyloid AngiopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.