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Article

CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation.

Translational neurodegeneration - 19 Dec 2024

Xue Yan-Yan, Zhang Zhe-Sheng, Lin Rong-Rong, Huang Hui-Fen, Zhu Ke-Qing, Chen Dian-Fu, Wu Zhi-Ying, Tao Qing-Qing

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. However, the precise mechanisms by which CD2AP is linked to AD pathogenesis remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39696695
DOI: 10.1186/s40035-024-00454-5
PMCID: PMC11657702

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