Article

FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer’s Disease

2024-05-09

Abstract excerpt

<h4>ABSTRACT</h4> FAM19A5, a novel secretory protein highly expressed in the brain, is potentially associated with the progression of Alzheimer’s disease (AD). However, its role in the AD brain remains unclear. Here, we investigated the potential function of FAM19A5 in the context of AD. We generated APP/PS1 mice with partial FAM19A5 deficiency, termed APP/PS1/FAM19A5 +/LacZ mice. Compared to control APP/PS1 mic...

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Literature Corpus work: 215475f0-2b2e-5cc1-961b-afd658daaa8f
DOI: 10.1101/2024.05.08.593243

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