Article
Metabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: An investigation at the protein level.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2020
Dekker Lennard J M, Wu Suying, Jurriëns Cherise, Mustafa Dana A N, Grevers Frederieke, Burgers Peter C, Sillevis Smitt Peter A E, Kros Johan M, Luider Theo M
Abstract excerpt
The discovery of the IDH1 R132H (IDH1 mut) mutation in low-grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in glioma metabolism. In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA cycle are associated with IDH1 mut. Here, we apply proteomics to FFPE samples of diffuse gliomas with or without IDH1...
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