Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.

doi:10.1093/neuonc/noz207

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.

Neuro-oncology - 15 Apr 2020

Ruiz-Rodado Victor, Malta Tathiane M, Seki Tomohiro, Lita Adrian, Dowdy Tyrone, Celiku Orieta, Cavazos-Saldana Alejandra, Li Aiguo, Liu Yang, Han Sue, Zhang Wei, Song Hua, Davis Dionne, Lee Sunmin, Trepel Jane B, Sabedot Thais S, Munasinghe Jeeva, Yang Chunzhang, Herold-Mende Christel, Gilbert Mark R, Cherukuri Murali Krishna, Noushmehr Houtan, Larion Mioara

Abstract excerpt

BACKGROUND: Early detection of increased aggressiveness of brain tumors is a major challenge in the field of neuro-oncology because of the inability of traditional imaging to uncover it. Isocitrate dehydrogenase (IDH)-mutant gliomas represent an ideal model system to study the molecular mechanisms associated with tumorigenicity because they appear indolent and non-glycolytic initially, but eventually a subset...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Glioma

Share to Glioma Diagnosis and Treatment

Share to Guanine

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 31665443
DOI: 10.1093/neuonc/noz207
PMCID: PMC7158660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.PMID 31665443Read ↗

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma.Semantic proximity Read ↗

Cancer metabolism as a central driving force of glioma pathogenesis.Semantic proximity Read ↗

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 MutationSemantic proximity Read ↗

Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype.Semantic proximity Read ↗

Metabolic reprogramming in mutant IDH1 glioma cells.Semantic proximity Read ↗

The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant GliomaSemantic proximity Read ↗

Metabolism of glioma and IDH1/IDH2 mutations.Semantic proximity Read ↗

Metabolic modulation of epigenetics in gliomas.Semantic proximity Read ↗

Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and BeyondSemantic proximity Read ↗

Oncometabolite? IDH1 Discoveries Raise Possibility of New Metabolism Targets in Brain Cancers and LeukemiaSemantic proximity Read ↗

Metabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: An investigation at the protein level.Semantic proximity Read ↗

Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of “metabolism‐based pathology”Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.