Article
Metabolism of glioma and IDH1/IDH2 mutations.
Revue neurologique - 1 Oct 2011
Rossetto M, Ciccarino P, Boisselier B, Labussiere M, Sanson M
Abstract excerpt
Many known oncogenic signaling pathways involved in gliomagenesis have strong consequences on tumor cell metabolism, and promote the switch from oxidative phosphorylation to aerobic glycolysis, for ATP generation. However, the interest on metabolism has been recently renewed by the discovery of recurrent mutation of IDH1 genes by systematic sequencing of a glioblastoma series. IDH1 encodes the cytoplasmic NADP...
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