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IDH Mutations in Glioma: Molecular, Cellular, Diagnostic, and Clinical Implications

30 Oct 2024

Abstract excerpt

In 2021, the World Health Organization classified isocitrate dehydrogenase (IDH) mutant gliomas as a distinct subgroup of tumors with genetic changes sufficient to enable a complete diagnosis. Patients with an IDH mutant glioma have improved survival which has been further enhanced by the advent of targeted therapies. IDH enzymes contribute to cellular metabolism, and mutations to specific catalytic residues...

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PMID: 39596840
DOI: 10.3390/biology13110885

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