Article
Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2019
Lenting Krissie, Khurshed Mohammed, Peeters Tom H, van den Heuvel Corina N A M, van Lith Sanne A M, de Bitter Tessa, Hendriks Wiljan, Span Paul N, Molenaar Remco J, Botman Dennis, Verrijp Kiek, Heerschap Arend, Ter Laan Mark, Kusters Benno, van Ewijk Anne, Huynen Martijn A, van Noorden Cornelis J F, Leenders William P J
Abstract excerpt
Diffuse gliomas often carry point mutations in isocitrate dehydrogenase ( IDH1mut), resulting in metabolic stress. Although IDHmut gliomas are difficult to culture in vitro, they thrive in the brain via diffuse infiltration, suggesting brain-specific tumor-stroma interactions that can compensate for IDH-1 deficits. To elucidate the metabolic adjustments in clinical IDHmut gliomas that contribute to their...
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