Article
Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.
PloS one - 1 Jan 2014
Izquierdo-Garcia Jose L, Cai Larry M, Chaumeil Myriam M, Eriksson Pia, Robinson Aaron E, Pieper Russell O, Phillips Joanna J, Ronen Sabrina M
Abstract excerpt
BACKGROUND: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert α-ketoglutarate to 2-hydroxyglutarate, ultimately leading to tumorigenesis. The major source of 2-hydroxyglutarate production is glutamine, which, in cancer, is also a source for tricarboxylic acid cycle (TCA) anaplerosis....
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