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Article

Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2.

Current opinion in oncology - 1 Jan 2012

Borodovsky Alexandra, Seltzer Meghan J, Riggins Gregory J

Abstract excerpt

PURPOSE OF REVIEW: IDH1/2 mutations occur in up to 70% of low-grade gliomas and secondary glioblastomas. Mutation of these enzymes reduces the wildtype function of the enzyme (conversion of isocitrate to α-ketoglutarate) while conferring a new enzymatic function, the production of D-2-hydroxyglutarate (D-2-HG) from α-ketoglutarate (α-KG). However, it is unclear how these enzymatic changes contribute to...

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Brain Neoplasms
Cancer, Hypoxia, and Metabolism
IDH1 gene
IDH2 gene
Glioma
Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

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Identifiers

PMID: 22080945
DOI: 10.1097/CCO.0b013e32834d816a
PMCID: PMC4612588

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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