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Article

Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation.

Journal of neuro-oncology - 1 Mar 2020

Ferreira Monica Sofia Ventura, Sørensen Mia Dahl, Pusch Stefan, Beier Dagmar, Bouillon Anne-Sophie, Kristensen Bjarne Winther, Brümmendorf Tim Henrik, Beier Christoph Patrick, Beier Fabian

Abstract excerpt

PURPOSE: Isocitrate dehydrogenase 1 (IDH1) mutations are associated with improved survival in gliomas. Depending on the IDH1 status, TERT promoter mutations affect prognosis. IDH1 mutations are associated with alpha-thalassemia/mental retardation syndrome X-linked (ATRX) mutations and alternative lengthening of telomeres (ALT), suggesting an interaction between IDH1 and telomeres. However, little is known how...

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Identifiers

PMID: 31960234
DOI: 10.1007/s11060-020-03394-y
PMCID: PMC7076064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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