The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.

doi:10.1038/modpathol.2013.90

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Article

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2013

Abedalthagafi Malak, Phillips Joanna J, Kim Grace E, Mueller Sabine, Haas-Kogen Daphne A, Marshall Roxanne E, Croul Sidney E, Santi Mariarita R, Cheng Jing, Zhou Shengmei, Sullivan Lisa M, Martinez-Lage Maria, Judkins Alexander R, Perry Arie

Abstract excerpt

Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-grade astrocytomas comprise a heterogeneous group of central nervous system tumors. We examined a large cohort of adult (91) and pediatric (n=88) high-grade astrocytomas as well as lower grade forms (n=35) for immunohistochemical loss...

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PMID: 23765250
DOI: 10.1038/modpathol.2013.90
PMCID: PMC6054791

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ATRX
PDGFRA

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The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.PMID 23765250Read ↗

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