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Article

Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas.

Brain pathology (Zurich, Switzerland) - 1 May 2013

Nguyen Doreen N, Heaphy Christopher M, de Wilde Roeland F, Orr Brent A, Odia Yazmin, Eberhart Charles G, Meeker Alan K, Rodriguez Fausto J

Abstract excerpt

Recent studies suggest that the telomere maintenance mechanism known as alternative lengthening of telomeres (ALT) is relatively more common in specific glioma subsets and strongly associated with ATRX mutations. We retrospectively examined 116 high-grade astrocytomas (32 pediatric glioblastomas, 65 adult glioblastomas, 19 anaplastic astrocytomas) with known ALT status using tissue microarrays to identify...

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Identifiers

PMID: 22928601
DOI: 10.1111/j.1750-3639.2012.00630.x
PMCID: PMC3827727

Genes

ATRX
DAXX
EGFR
IDH1

Variants

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Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas.PMID 22928601Read ↗

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Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma.Semantic proximity Read ↗

Functional Assessment of ATRX Alterations Improves Glioma DiagnosisSemantic proximity Read ↗

Functional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas.Semantic proximity Read ↗

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