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Article

Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma.

Cancer research - 1 Jun 2018

Mukherjee Joydeep, Johannessen Tor-Christian, Ohba Shigeo, Chow Tracy T, Jones Lindsey, Pandita Ajay, Pieper Russell O

Abstract excerpt

A subset of tumors use a recombination-based alternative lengthening of telomere (ALT) pathway to resolve telomeric dysfunction in the absence of TERT. Loss-of-function mutations in the chromatin remodeling factor ATRX are associated with ALT but are insufficient to drive the process. Because many ALT tumors express the mutant isocitrate dehydrogenase IDH1 R132H, including all lower grade astrocytomas and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29545335
DOI: 10.1158/0008-5472.CAN-17-2269
PMCID: PMC10578296

Genes

ATRX
IDH1
XRCC1
TERT

Variants

Provenance

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Related research

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Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma.PMID 29545335Read ↗

Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation.Semantic proximity Read ↗

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific mannerSemantic proximity Read ↗

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation ProcessSemantic proximity Read ↗

Functional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas.Semantic proximity Read ↗

Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas.Semantic proximity Read ↗

Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas.Semantic proximity Read ↗

Functional Assessment of ATRX Alterations Improves Glioma DiagnosisSemantic proximity Read ↗

ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma.Semantic proximity Read ↗

Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells.Semantic proximity Read ↗

Cancer-associated <i>SMARCAL1</i> loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cellsSemantic proximity Read ↗

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.Semantic proximity Read ↗

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.Semantic proximity Read ↗

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