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Article

WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation.

Cell cycle (Georgetown, Tex.) - 1 Feb 2020

Choi Byung-Kwon, Fujiwara Kenichiro, Dayaram Tajhal, Darlington Yolanda, Dickerson Joshua, Goodell Margaret A, Donehower Lawrence A

Abstract excerpt

The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibitor p27Kip1 that promotes G1 arrest. ATM activates p27Kip1-induced arrest in part through phosphorylation of p27Kip1 at Serine 140. Here we show that this site is dephosphorylated by the type 2C serine/threonine...

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Identifiers

PMID: 31959038
DOI: 10.1080/15384101.2020.1717025
PMCID: PMC7100888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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