Article
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Cancer cell - 1 Oct 2007
Lu Xiongbin, Ma Ou, Nguyen Thuy-Ai, Jones Stephen N, Oren Moshe, Donehower Lawrence A
Abstract excerpt
The tumor suppressor p53 is a transcription factor that responds to cellular stresses by initiating cell cycle arrest or apoptosis. One transcriptional target of p53 is Mdm2, an E3 ubiquitin ligase that interacts with p53 to promote its proteasomal degradation in a negative feedback regulatory loop. Here we show that the wild-type p53-induced phosphatase 1 (Wip1), or PPM1D, downregulates p53 protein levels by...
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