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Article

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Oncogene - 1 Mar 2012

Darlington Y, Nguyen T-A, Moon S-H, Herron A, Rao P, Zhu C, Lu X, Donehower L A

Abstract excerpt

Wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that dephosphorylates proteins in the ataxia telangiectasia mutated (ATM)-initiated DNA damage response pathway. WIP1 may have a homeostatic role in ATM signaling by returning the cell to a normal pre-stress state following completion of DNA repair. To better understand the effects of WIP1 on ATM signaling, we crossed Atm-deficient mice...

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Source

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Identifiers

PMID: 21765465
DOI: 10.1038/onc.2011.303
PMCID: PMC3197977

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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