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Article

Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.

Cancer cell - 14 Oct 2013

Filipponi Doria, Muller Julius, Emelyanov Alexander, Bulavin Dmitry V

Abstract excerpt

Wip1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. We found that Wip1 plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences. Wip1 was required for epigenetic remodeling of repetitive DNA elements through regulation of BRCA1 interaction with HP1, the recruitment of DNA methyltransferases, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24135283
DOI: 10.1016/j.ccr.2013.08.022

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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