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Article

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.

The Journal of cell biology - 13 May 2013

Kleiblova Petra, Shaltiel Indra A, Benada Jan, Ševčík Jan, Pecháčková Soňa, Pohlreich Petr, Voest Emile E, Dundr Pavel, Bartek Jiri, Kleibl Zdenek, Medema René H, Macurek Libor

Abstract excerpt

The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an intrinsic barrier preventing cancer development. The serine/threonine phosphatase PPM1D/Wip1 inactivates p53 and promotes termination of the DDR pathway. Wip1 has been suggested to act as an oncogene in a subset of tumors that retain wild-type p53. In this paper,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23649806
DOI: 10.1083/jcb.201210031
PMCID: PMC3653305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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