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The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stability

15 Jan 2008

Abstract excerpt

The p53 tumor suppressor is essential in maintaining genomic integrity in response to cellular stresses. In response to DNA damage, p53 is activated and stabilized largely through post-translational modifications, including phosphorylation by DNA damage responsive kinases such as ATM and ATR. Activated p53 transactivates a battery of genes that can mediate either cell cycle arrest or apoptosis. In those instances...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18333294
DOI: 10.4161/cc.7.2.5299

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The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stabilityPMID 18333294Read ↗

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