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Article

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.

Cell cycle (Georgetown, Tex.) - 1 Aug 2005

Lu Xiongbin, Nguyen Thuy-Ai, Donehower Lawrence A

Abstract excerpt

The eukaryotic cell has evolved a sophisticated set of cell signaling pathways that respond to DNA damage and efficiently repair that damage, protecting the cell from deleterious mutations, genomic instability, and transformation into a cancerous state. The ATM and ATR serine/threonine kinases ar...

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Source

Identifiers

PMID: 15970689

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15970689-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.PMID 15970689Read ↗

The role of PPM1D in cancer and advances in studies of its inhibitorsSemantic proximity Read ↗

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.Semantic proximity Read ↗

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The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathwaysSemantic proximity Read ↗

WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation.Semantic proximity Read ↗

The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stabilitySemantic proximity Read ↗

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.Semantic proximity Read ↗

Genetic variants and mutations of PPM1D control the response to DNA damage.Semantic proximity Read ↗

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sitesSemantic proximity Read ↗

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.Semantic proximity Read ↗

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.Semantic proximity Read ↗

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.Semantic proximity Read ↗

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