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Article

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.

Cancer research - 15 Oct 2009

Zhang Xinna, Lin Lin, Guo Huarong, Yang Jianhua, Jones Stephen N, Jochemsen Aart, Lu Xiongbin

Abstract excerpt

MdmX and Mdm2 regulate p53 tumor suppressor functions by controlling p53 transcriptional activity and/or stability in cells exposed to DNA damage. Accumulating evidence indicates that ATM-mediated phosphorylation and degradation of Mdm2 and MdmX may be the initial driving force that induces p53 a...

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Source

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Identifiers

PMID: 19808970
DOI: 10.1158/0008-5472.CAN-09-0634
PMCID: PMC2763051

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19808970-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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