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Article

The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers.

Journal of Parkinson's disease - 1 Mar 2025

Goldstein Orly, Shani Shachar, Gana-Weisz Mali, Elkoshi Nadav, Casey Fergal, Sun Yu H, Chandratre Khyati, Cedarbaum Jesse M, Blauwendraat Cornelis, Bar-Shira Anat, Thaler Avner, Gurevich Tanya, Mirelman Anat, Giladi Nir, Orr-Urtreger Avi, Alcalay Roy N

Abstract excerpt

BackgroundWhile LRRK2 and GBA1 variants are associated with Parkinson's disease (PD), most carriers will not develop the disease.ObjectiveTo test if polygenic risk score (PRS) modifies disease risk and phenotypes in LRRK2 G2019S carriers, GBA1 carriers, and non-carriers (NC).MethodsWe genotyped 786 participants using Illumina's NeuroBooster-array (NBA) and sequenced the genome of 244, all of Ashkenazi ancestry...

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Identifiers

PMID: 39973498
DOI: 10.1177/1877718X241310722
PMCID: PMC13347430

Genes

GBA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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