Article

An improved polygenic score for Parkinson’s disease partly explains variable penetrance of genetic Parkinson’s disease

2025-03-04

Abstract excerpt

While genetic causes are identified in up to 15% of all Parkinson’s disease (PD) patients, the remaining idiopathic PD (iPD) patients are attributed to polygenic risk, environmental and lifestyle factors, and interactions thereof. We applied five advanced polygenic score (PGS) tools to data from 1,762 iPD patients and 4,227 healthy controls of European ancestry, resulting in the development of a novel iPD-PGS with...

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Literature Corpus work: 55bbe1db-f620-55c7-b4a4-818a8b39915c
DOI: 10.1101/2025.02.28.25323076

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