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Article

Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

19 Jan 2020

Abstract excerpt

While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its role in cancer metastasis is entirely unknown. Hence, we sought to determine the effects of NOD1 on metastasis. NOD1 expression in paired human primary colon cancer, human and murine colon cancer...

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PMID: 31956962
DOI: 10.1007/s13238-019-00687-5

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