Article

Endothelial cell-intrinsic NOD2 signaling regulates the intestinal immune response through the generation of effector and memory T cells

2025-09-11

Abstract excerpt

<h4>Summary</h4> Crohn’s disease (CD) is marked by vascular endothelial dysfunction and aberrant T cell immunity in the gastrointestinal tract. However, mechanistic understanding is lacking of how CD-associated gene variants, particularly those that compromise NOD2 function, impact the intestinal vascular endothelium and orchestration of T cell immunity. Here, we find that NOD2, when triggered by its ligand, mura...

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Literature Corpus work: 9e2c7d63-e984-5e12-b2ea-84a427e50efd
DOI: 10.1101/2025.09.06.674650

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