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Article

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2011

Hasegawa Mizuho, Yamazaki Takashi, Kamada Nobuhiko, Tawaratsumida Kazuki, Kim Yun-Gi, Núñez Gabriel, Inohara Naohiro

Abstract excerpt

Clostridium difficile is a Gram-positive obligate anaerobic pathogen that causes pseudomembranous colitis in antibiotics-treated individuals. However, host immune protective mechanisms against C. difficile are largely unknown. In this study, we show that C. difficile possesses potent stimulatory activity for nucleotide-binding oligomerization domain 1 (Nod1), an intracellular pattern recognition molecule that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21411735
DOI: 10.4049/jimmunol.1003761

Genes

CCL2
CXCL1
XCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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