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Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review

26 Apr 2018

Abstract excerpt

Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular innate immune sensor for small molecules derived from bacterial cell components. NOD1 activation by its ligands leads to robust production of pro-inflammatory cytokines and chemokines by innate immune cells, thereby mediating mucosal host defense systems against microbes. Chronic gastric infection due to Helicobacter pylori (H. pylori ) causes...

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PMID: 29713127
DOI: 10.3748/wjg.v24.i16.1725

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