Article
The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish.
Disease models & mechanisms - 1 Nov 2011
Oehlers Stefan H, Flores Maria Vega, Hall Chris J, Swift Simon, Crosier Kathryn E, Crosier Philip S
Abstract excerpt
Inflammatory bowel disease (IBD), in the form of Crohn's disease (CD) or ulcerative colitis (UC), is a debilitating chronic immune disorder of the intestine. A complex etiology resulting from dysfunctional interactions between the intestinal immune system and its microflora, influenced by host genetic susceptibility, makes disease modeling challenging. Mutations in NOD2 have the highest disease-specific risk...
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