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The innate immune molecule, NOD1, regulates direct killing of<i>Helicobacter pylori</i>by antimicrobial peptides

21 Dec 2009

Abstract excerpt

The cytosolic innate immune molecule, NOD1, recognizes peptidoglycan (PG) delivered to epithelial cells via the Helicobacter pylori cag pathogenicity island (cagPAI), and has been implicated in host defence against cagPAI(+)H. pylori bacteria. To further clarify the role of NOD1 in host defence, we investigated NOD1-dependent regulation of human beta-defensins (DEFBs) in two epithelial cell lines. Our findings...

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PMID: 20039881
DOI: 10.1111/j.1462-5822.2009.01421.x

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