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Article

Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape.

Nature communications - 17 Jan 2020

Quadeer Ahmed A, Barton John P, Chakraborty Arup K, McKay Matthew R

Abstract excerpt

Vaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists. To investigate this, we infer a fitness model for the poliovirus viral protein 1 (vp1), which successfully predicts in vitro fitness measurements. This is achieved by first developing a probabilistic model for the prevalence of vp1 sequences that enables us to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31953427
DOI: 10.1038/s41467-019-14174-2
PMCID: PMC6969152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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