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Article

The Early Evolution of Oral Poliovirus Vaccine Is Shaped by Strong Positive Selection and Tight Transmission Bottlenecks.

Cell host & microbe - 13 Jan 2021

Valesano Andrew L, Taniuchi Mami, Fitzsimmons William J, Islam Md Ohedul, Ahmed Tahmina, Zaman Khalequ, Haque Rashidul, Wong Wesley, Famulare Michael, Lauring Adam S

Abstract excerpt

The emergence of circulating vaccine-derived polioviruses through evolution of the oral polio vaccine (OPV) poses a significant obstacle to polio eradication. Understanding the early genetic changes that occur as OPV evolves and transmits is important for preventing future outbreaks. Here, we use deep sequencing to define the evolutionary trajectories of type 2 OPV in a vaccine trial. By sequencing 497...

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Source

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Identifiers

PMID: 33212020
DOI: 10.1016/j.chom.2020.10.011
PMCID: PMC7815045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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