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Article

Computational design of hepatitis C virus immunogens from host-pathogen dynamics over empirical viral fitness landscapes.

Physical biology - 28 Nov 2018

Hart Gregory R, Ferguson Andrew L

Abstract excerpt

Hepatitis C virus (HCV) afflicts 170 million people and kills 700 000 annually. Vaccination offers the most realistic and cost effective hope of controlling this epidemic, but despite 25 years of research, no vaccine is available. A major obstacle is HCV's extreme genetic variability and rapid mutational escape from immune pressure. Coupling maximum entropy inference with population dynamics simulations, we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30484433
DOI: 10.1088/1478-3975/aaeec0

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