Structural considerations in the fitness landscape of a virus.

doi:10.1093/molbev/msq056

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Structural considerations in the fitness landscape of a virus.

Molecular biology and evolution - 1 Aug 2010

Watabe Teruaki, Kishino Hirohisa

Abstract excerpt

Viral fitness is determined by replication within hosts and transmission between them. We examine how pleiotropic mutations that have antagonistic effects (i.e., antibody evasion vs. receptor binding) on viral replication within hosts can impact viral immune escape in the host population. When the host population is vaccinated, the virus escapes from passive immunity by mutations in the antibody-binding region on...

Topics

Biological Evolution
Genetic Fitness
Humans
Models, Molecular
Models, Theoretical
Mutation
Protein Structure, Tertiary
Severe acute respiratory syndrome-related coronavirus
Vaccination
Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 20194425
DOI: 10.1093/molbev/msq056
PMCID: PMC7187634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics