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Article

Structural considerations in the fitness landscape of a virus.

Molecular biology and evolution - 1 Aug 2010

Watabe Teruaki, Kishino Hirohisa

Abstract excerpt

Viral fitness is determined by replication within hosts and transmission between them. We examine how pleiotropic mutations that have antagonistic effects (i.e., antibody evasion vs. receptor binding) on viral replication within hosts can impact viral immune escape in the host population. When the host population is vaccinated, the virus escapes from passive immunity by mutations in the antibody-binding region on...

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Identifiers

PMID: 20194425
DOI: 10.1093/molbev/msq056
PMCID: PMC7187634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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