Article

A reusable model of pangenome selection informs optimal surveillance strategies over vaccine introductions

2025-12-21

Abstract excerpt

The human pathogen Streptococcus pneumoniae is a major cause of disease, including pneumonia and meningitis. The introduction of Pneumococcal Conjugate Vaccines (PCVs) initially reduced the burden of disease through a reduction of colonisation by vaccine-targeted serotypes. However, since PCVs only target a proportion of pneumococcal serotypes, they shift intraspecific competition, eventually allowing non-targeted...

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Literature Corpus work: 72ccd13c-6bd2-53e3-a67f-ca7ef700c5d6
DOI: 10.64898/2025.12.18.695090

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