Article
Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Dec 2013
Shekhar Karthik, Ruberman Claire F, Ferguson Andrew L, Barton John P, Kardar Mehran, Chakraborty Arup K
Abstract excerpt
Mutational escape from vaccine-induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus' fitness as a function of its proteomic sequence can enable rational design of potent vaccines, as this information can focus vaccine-induced immune responses to target mutational vulnerabilities of the virus. Spin models...
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